IL6 and diabetes mellitus: In this context, the purpose of this study was to investigate the potential mechanisms involved in the spontaneous onset of diabetes-triggered periodontitis through the quantitative and spatial evaluation of RAGE, TNF-alpha, IL-1beta, IL-6, RANKL, MMP-2, MMP-9 immunostaining patterns, and also the monitoring of oral microbiota load, in periodontal tissue in rats after 1, 3, 6, 9, and 12 months of diabetes induction.