In the vertebrates the better characterized aspect of lack of Bic-C function is the induction of cystic kidneys and the alteration of cell proliferation and three dimensional organization; however, defects in pancreatic and liver function and heterotaxia (i.e., randomization of the left-right symmetry) of the visceral organs have also been observed [26, 27]. The gene discussed is BICC1; the disease is Renal cyst.