Moreover, we attempted to determine the relationship between the apoptosis and COX-2 expression in this gastric adenocarcinoma cells infected with Hp strain and co-incubated with exogenous CagA to check whether recombinant CagA protein will aggravate the alterations in expression in HSP70, Bax and Bcl-2 proteins in the absence and presence of Hp. Here, S100A8 is linked to gastric adenocarcinoma.