Most in vitro and animal studies have shown that both Hp cagA positive and Hp cagA negative strains enhanced apoptosis sometimes with no relation to CagA expression [27, 34, 37, 38] suggesting that our results with Hp infection of cancer cell line seems to mimic those obtained in normal gastric epithelial cells with respect to apoptosis at early time after infection. The gene discussed is S100A8; the disease is infection.