LMNA and Hutchinson-Gilford progeria syndrome: OST-P expression, in contrast to OST-A, leads to distortions of the nuclear lamina (ESM Figs. S1 and S4a) and global loss of LAP2 and HP1γ nuclear levels (Kubben et al. 2010) similar to the cellular phenotypes observed in HGPS patient cells (Scaffidi and Misteli 2006), further indicating the full functionality of OST-tagged lamin A and progerin in MEFs.