LMNA and Hutchinson-Gilford progeria syndrome: The most dramatic laminopathy-associated chromatin reorganization occurs in the premature aging disease Hutchinson–Gilford progeria syndrome (HGPS), where the disease-causing mutant lamin A isoform progerin causes loss of heterochromatin and reduces mono- and trimethylation of lysines 9 and 20 on histone 3 (Scaffidi and Misteli 2006; Goldman et al. 2004).