Cyp2d26 (42-fold; 2 AHR REs) is a candidate gene for the regulation of triglyceride levels (Leduc et al. 2011); Gadd45g (2.50-fold; 12 AHR REs) encodes a protein that functions in T-cell production (Chi et al. 2004); the product of Bhmt (2.09-fold; 7 AHR REs) is associated with liver steatosis and injury and protects hepatocytes from endoplasmic reticulum stress and excess lipid accumulation (Ji et al. 2007); and the obesity-associated Sqle (↓0.52-fold; 8 AHR REs) gene encodes a protein that carries out a step in cholesterol biosynthesis (Yamamoto and Bloch 1970). The gene discussed is AHR; the disease is obesity due to melanocortin 4 receptor deficiency.