Genes relevant to obesity expressed uniquely in the B6R/B6.D2R comparison included Ppp1r3c and Elovl3. The Ppp1r3c (2.3-fold) gene product is involved in glycogen storage in adipocytes (Greenberg et al. 2006), and loss of the Elovl3 (2.2-fold) gene in mice causes reduced adiponectin levels, inhibition of adipose tissue expansion, and resistance to diet-induced obesity (Zadravec et al. 2010). The gene discussed is ELOVL3; the disease is obesity due to melanocortin 4 receptor deficiency.