Moreover, the spatial pattern of mineral particle alignment, which is found to be highest in the femoral cortical midshaft and decreases toward the metaphyses and systematically increases with age in wild-type mice, is lost in TNALP-deficient mice, which is a model for hypophosphatasia; these changes could be due to a disruption of a highly ordered metaphyseal bone matrix due to ongoing remodelling in the cortical midshaft [4]. This evidence concerns the gene ALPL and hypophosphatasia.