Five informative tumors had genomic amplifications of known cancer genes, three involving ERBB2 and one each involving MYC and CCND1. In four of the five cases, no mutations were present on all copies of the amplified segment, even allowing for the one patient where both parental copies of the locus contributed to the amplification (Figures S5B and S5C). The gene discussed is CCND1; the disease is cancer.