EIF4EBP1 and cancer: To date, extensive published work demonstrated the impact of mTOR on cell growth, cancer cell proliferation and resistance to cytotoxic agents [5] mTORC1 regulates multiple growth and gene expression pathways and specifically stimulates mRNA translation through phosphorylation and activation of the ribosomal p70S6-kinase (p70s6k) and phosphorylation-induced inhibition of the translation initiation inhibitor eIF4E binding protein 1 (4EBP1) [5].