Skeletal muscle from EDMD patients and emerin-null mice also exhibit increased expression of Rb-MyoD pathway components including CBP and p300 [8], [9] and prolonged phosphorylation of Rb1 [8], which was associated with delayed MyoD activity and impaired skeletal muscle regeneration. The gene discussed is RB1; the disease is Emery-Dreifuss muscular dystrophy.