Interestingly, RNAi of DPP3 using siDPP3 significantly (p<0.05) increased CRE/CREB activation under mock-infected conditions despite DPP3 not being implicated in the CRE/CREB pathway, and silencing of ADAMTS7 significantly (p<0.05) abrogated CRE/CREB activation during infection. The gene discussed is CREB1; the disease is infection.