CRH and major depressive disorder: Reppermund et al. [23] studied 75 inpatients with major depressive disorder and revealed that slowed speed of information processing measured by averaging the time of two matrices of the Zahlenverbindungstest was associated with more mood symptoms, whereas improvement of verbal short term memory was associated with decreased cortisol response, which was evaluated with the dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test.