IL1B and psoriasis: Moreover, the gene dysregulation profile induced by epidermal PPAR β/δ activation significantly overlaps with that characteristic of psoriasis, including faithful replication of well recognised functional clusters such as the entire Il1-module or the cholesterol biosynthesis program, suggesting that the subsets of genes dysregulated by PPAR β/δ activation are also regulated by PPAR β/δ in psoriasis.