When examining the risk of having a positive coronary calcification score (as a binary variable), we found the Framingham score (OR 1.3, 95% CI 1.1, 1.5) and PAI-1/TPA (OR 1.3, 95% CI 1.0, 1.6) were associated with a positive coronary calcification score in the multivariable model. This evidence concerns the gene SERPINE1 and calcification.