To maintain equality between the output lists of LSI-correlating proteins from the diverse input KEGG terms used (1-Regulation of actin cytoskeleton, 2-Chemokine signaling, 3-Alzheimer's disease, 4-Focal adhesion, 5-MAPK signaling, 6-Gap junction, 7-GnRH signaling, 8-Long term potentiation, 9-Notch signaling, 10-VEGF signaling, 11-p53 signaling, 12-Calcium signaling), we chose the top 1000 highest-scoring proteins in each case (terms 1–12). The gene discussed is GNRH1; the disease is early-onset autosomal dominant Alzheimer disease.