Whereas co-infection with WT vaccinia significantly attenuated the induction of IFN-α and TNF by myxoma virus, Heat-VAC or CpG, co-infection with ΔE3L or E3LΔ83N virus only partially reduced IFN-α and TNF secretion (Fig. 8A, B and C). This evidence concerns the gene IFNA1 and coinfection.