In the stratified analyses, the results showed that the association between the CCND1 G870A polymorphism and CRC risk remained significant in Caucasians and sCRC but not in Asians or HNPCC, which supports the hypothesis that genetic backgrounds and the environment in which patients live in might play important roles in the development of CRC [5]. This evidence concerns the gene CCND1 and colorectal carcinoma.