The Fzd8 soluble extracellular domain suppresses Wnt-driven tumor growth in vivo[10] and two sFRPs, FrzA and FrzB inhibited Wnt-1–mediated increase in cytoplasmic β-catenin levels, TCF transcriptional activity in vitro, and tumor growth and metastasis [37]. The gene discussed is SFRP1; the disease is neoplasm.