In addition, it is noteworthy that (i) genetically determined overexpression of FGF1 in the mesangial cells of kidneys correlates with hereditary hypertension [25]; (ii) FGF2 is implicated in pulmonary hypertension [26], (iii) FGF1 released by EC is a key stimulator of adipogenesis and thus can be involved in obesity [27]. This evidence concerns the gene FGF2 and obesity due to melanocortin 4 receptor deficiency.