As a means to search for new therapeutic targets, we have applied genome wide transcriptional profiling, systems biology, and pathway analysis techniques to further examine the curative impact of PM [5] and AAT [4] regimens upon pancreatic lymph nodes, a relevant immune system site and fat, a site for insulin directed glucose disposal, in new onset T1D/T2D NOD mice. This evidence concerns the gene INS and type 2 diabetes mellitus.