INS and diabetes mellitus: The merging of the three significantly effected networks generated a complex network with regulatory hubs formed by inflammation related genes (e.g. TNF-α, NF-κB), kinases (e.g. AKT, PI-3 kinase), and transcriptional regulators (HNF4A, EGR1, Jnk) as well as diabetes related genes (Insulin, Ins1) (Fig. 3).