Similar to univariate analysis, after adjustment, amplification of ERBB4 (OR = 2.95, 95% CI = 1.27–6.86, P < 0.05) and CD44 (OR = 2.49, 95% CI = 1.08–5.79, P < 0.05) remained significantly associated with poor tumor differentiation (Table 2). This evidence concerns the gene CD44 and neoplasm.