In subsequent studies of patients with MFRP mutations, consistent features frequently reported are the early onset of visual loss [24], the presence of high hyperopia, diminished ERG responses with a rod-cone pattern, and RPE atrophy [20,21]; occasional or inconsistent features include night blindness, hyperpigmentation of the retina, foveoschisis, macular cysts, and optic nerve drusen [22,24]. This evidence concerns the gene MFRP and macular holes.