The most significant SNP in the POAG risk analysis is located in NEDD9. There was strong evidence from surrounding SNPs and NEDD9 appears an excellent candidate as it has been shown to be increased in trabecular meshwork cells [23], however, none of the 3 SNPs chosen for follow-up in the NEDD9 region were significant in the replication study. Here, NEDD9 is linked to open-angle glaucoma.