Although the effects of varying expression levels of RPS10 (encodes a ribosomal protein), ETV6 (encodes a transcription factor), and H3F3B (encodes a histone protein) on the malignant phenotype are less well defined, their presence in the 5-gene rule are not inappropriate for a molecular signature of a tumor's inherent aggressiveness. This evidence concerns the gene ETV6 and neoplasm.