The best understood of these is the DENND1 subfamily, which has been shown to control Rab35 in an endocytic pathway required for yolk protein receptor recycling in C. elegans, MHC-I recycling in mammals, and the uptake of the causative agent of shigellosis – Shiga toxin (Allaire et al., 2010; Sato et al., 2008; Yoshimura et al., 2010). This evidence concerns the gene RAB35 and shigellosis.