Third, according to the ABCD algorithm [39,40] both treatment arms of NOAAH include a drug class that addresses the low-renin volume component of hypertension (hydrochlorothiazide and amlodipine) as well as agents (bisoprolol and valsartan) interfering with the high-renin vasoconstrictor component [40]. The gene discussed is REN; the disease is Hypertension.