TNFRSF8 and primary cutaneous T-cell non-Hodgkin lymphoma: MF and SS have variable expression of CD30 and hence a phase II single arm open label exploratory study evaluating the biologic effects of brentuximab vedotin in patients with CTCL is currently ongoing where patients regardless of their levels of CD30 expression (low, intermediate and high based on immunohistochemical studies) will be enrolled.