The GNAQ mutations were found in uveal melanoma and primary melanocytic lesions of the CNS (mutations in codon 209 of GNAQ form an alternative route to mitogen-activated protein kinase (MAPK) activation), while mutations of NRAS and BRAF were detected in metastatic lesions of the CNS, including LM (no involvement of HRAS was observed) [18]. Here, WNK2 is linked to uveal melanoma.