Previous functional study has reported that this intronic SNP has a regulatory effect on TLR9 expression, with the rs352139 G allele in combination with the promoter rs187084 (C-1486 T) C allele having a down-regulatory effect, while the rs352139 A allele in combination with rs187084 T allele having an up-regulatory effect on TLR9 expression among patients with systemic lupus erythematosus [30]. The gene discussed is TLR9; the disease is systemic lupus erythematosus.