In this study, we evaluated and compared the effects of ARB and CCB monotherapy on biochemical parameters including serum TG, TC, non-fasting blood glucose, HbA1c, sodium, potassium, creatinine, ALT, AST and GGT and hematological parameters including hemoglobin, hematocrit, and WBC, RBC and PLT counts in patients with mild to moderate hypertension and type 2 diabetes mellitus. This evidence concerns the gene GPT and diabetes mellitus.