It has been recently reported that one of the Nox isoforms, Nox4, is expressed in the mitochondria in the rat renal cortex [21], cardiac myocytes [22, 23], and in the mitochondria-enriched heavy membrane fractions of the chronic myeloid leukemia cells that overexpress the antiapoptotic protein Bcl-2 (CEM/Bcl-2) [24]. Here, BCL2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.