One of the most used fibrates, fenofibrate, has also shown to improve many other atherosclerosis-related variables, such as high sensitivity C-reactive protein (hsCRP), lipoprotein-associated phospholipase A2 (LpPLA2), apolipoprotein C-III (apoC-III), and reverse HDL cholesterol transport [1, 4–10]. The gene discussed is APOC3; the disease is atherosclerosis.