In both situations, MCL-like lymphomas express similar membrane B-cell differentiation markers (B220+CD19+IgM+IgD+ CD5+CD23−) but arise with different kinetics (3 months vs 6 months for c-myc-3'RR/p53+/− mice and c-myc-3'RR/Cdk4R24C mice, respectively), with a different proteomic signature (Cdk6/cyclin D complexes vs Cdk4/cyclin D complexes for c-myc-3'RR/p53+/− mice and c-myc-3'RR/Cdk4R24C mice, respectively), and in relation with a different mutational status (p53 deficiency vs disruption of Cdk4 regulation by INK4). The gene discussed is CDK4; the disease is mantle cell lymphoma.