EPB41L3 and lung adenocarcinoma: These include the up-regulation of growth promoting genes such as aldehyde dehydrogenase 1A1 (ALDH1A1) [25] and caveolin-1 (CAV1) [26], and down-regulation of growth suppressing genes like the tumor suppressor 4.1B/differentially expressed in adenocarcinoma of the lung-1 (DAL-1) [27].