RASGEF1A and cancer: In addition, expression of Kruppel-like factor 4 (KLF4) [28], Ras guanyl nucleotide exchange factor 1A (RASGEF1A) [29], and polo-like kinase 2 (PLK2) [30] have been reported to exhibit anti-apoptotic and growth-promoting activity in human cancer cells and are also up-regulated by RASSF1C over-expression.