Last, ectopic expression of PFKFB3 increases intracellular F2,6BP and protects Jurkat T cell leukemia cells from the cytostatic effects of 3PO whereas heterozygous PFKFB3+/− LT/ras-transformed fibroblasts that express decreased PFKFB3 protein and low F2,6BP compared to their wild-type isogenic counterparts have been found to be more sensitive to 3PO (21). The gene discussed is PFKFB3; the disease is T-cell leukemia.