In summary, as the in vivo thrombolytic efficacy of Δ(K2-K5) plasmin has been established in large animal models of arterial thrombosis, the primary focus of this study was to assess the ICH safety of Δ(K2-K5) plasmin administered after an extensive cerebral ischemic insult with recanalization. The gene discussed is PLG; the disease is Arterial thrombosis.