Ubiquitination mediated by the E3 ubiquitin ligase Cbl is a key post-translational protein modification in EGFR endocytosis in porcine aortic endothelial (PAE), Hela, and laryngeal carcinoma cell line Hep2 cells [16,17], as well as in EGFR degradation in Chinese hamster ovary (CHO) and human embryonic kidney (HEK) cell line 293 T cells [18,19]. Here, EGFR is linked to laryngeal carcinoma.