We recently demonstrated a genetic effect of sEH encoded by the EPHX2 gene on the progression of IgA nephropathy [13] and on renal allograft survival [14], and some studies have shown a protective effect of sEH inhibitors against IRI in stroke [15], [16] and ischemia-induced myocardial damage [17]–[19]. The gene discussed is EPHX2; the disease is stroke disorder.