Moreover, it is unlikely that they are activated terminally-differentiated CD8+ T-cells that lost CD8 expression, as suggested in other clinical settings associated with abnormal expansions of circulating DNαβ cells, such as autoimmune lymphoproliferative syndromes (ALPS) [45], given the lack of expression of markers of terminal differentiation. This evidence concerns the gene CD8A and autoimmune lymphoproliferative syndrome.