Perifosine has a similar structure to naturally occurring phospholipids that has been described to primarily interfere with membranes of proliferating cells like tumour cells, Here we demonstrate that 50% of Perifosine-induced MMe growth inhibition (IC50) in 24 hours was 23 μM, 14 μM and 7.5 μM for REN, MSTO211H, and MMP respectively, while minimal toxicity was displayed in HMC normal mesothelial cells (Figure 1A). Here, REN is linked to neoplasm.