The first one corresponded to K562 cell line, a model of Chronic Myelogenous Leukemia (CML) characterized by the presence of the oncogenic BCR-ABL fusion protein that possesses a higher tyrosine kinase activity than the normal c-Abl protein and thus drives the aberrant proliferation and malignancy of these cells [32]. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.