ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: As an ideal candidate for targeted therapy, several drugs have been developed against BCR-ABL, among which the frontline therapy for CML, imatinib (or Gleevec) [33] and the second generation BCR-ABL inhibitors (also efficient on imatinib resistant form of BCR-ABL) nilotinib (Tasigna) [34], [35] and dasatinib (Sprycel) [36].