In the myocardial infarction group there was a divergent reactivity, with marginal up-regulation of IGF-1 (P = 0.06) (Fig 6A), especially at the site of injury (Fig 6C) and significant (P<0.05) down-regulation of endogenous HGF (Fig 6C and D). The gene discussed is IGF1; the disease is myocardial infarction.