Unexpectedly, there was an inverted temporal response between c-Kit and Nkx2.5 expression following myocardial infarction, where c-Kit expression increased from week 1 to week 2 while Nkx2.5 expression reached its maximal level already after one week (Fig 2A, 3B). The gene discussed is NKX2-5; the disease is myocardial infarction.