Consistent with published findings [15], IFN-β tended to be reduced in the lungs of infected Nod2-/- mice as compared to WT animals during the early phase of infection and Nod2-/- alveolar macrophages produced significantly less IFN-β than WT cells in response to IAV (Figure 2F and Figure S2C). The gene discussed is IFNB1; the disease is infection.