We found that p53, p73, p21waf1/cip1, NOXA and Bax were significantly induced by cisplatin in p53-wild type A2780s cell line, but in other three p53-mutant ovarian cancer cell lines, the expressions of p73, p21waf1/cip1, NOXA and Bax remained unchanged. The gene discussed is PMAIP1; the disease is ovarian carcinoma.