BRCA1 and ovarian carcinoma: Recent reports have shown that p73, a member of p53 family proteins, is a key regulator of apoptosis susceptibility to cisplatin (Cis) in A2780 ovarian cancer cells [6], [7], and that p73-dependent transcriptional program is an important contributor to the chemosensitivity pathway in BRCA1-deficient ovarian carcinoma cells [8], indicating some mechanisms affecting p73 expressions and functions may contribute to the development of resistance to cisplatin-induced apoptosis in ovarian cancer cells [7].