TP53 and ovarian carcinoma: Considering that NOXA functions downstream of the p53-mediated apoptotic pathway, and that the cytotoxic action of cisplatin is mediated by DNA damage, which, in turn, transactivates target genes (e.g.p53AIP, PUMA, NOXA) to cause apoptosis, we predicts that elevated NOXA expression can sensitize ovarian cancer cells to cisplatin.