Then, we examined cisplatin-induced expression levels of p53, p73, p21waf1/cip1, NOXA and Bax in several human ovarian cancer cell lines with different p53 status including A2780s (p53 wild-type, p53 WT), SKOV3 (p53 double deletion mutant, p53-/-), OVCAR-3 (harboring mutant p53 R248Q) and A2780cp (containing p53 wild-type gene sequence but showing loss of p53 function) [13], [14]. This evidence concerns the gene PMAIP1 and ovarian cancer.