We further found that p53, p21waf1/cip1, which is indicative of a functional p53, p73, NOXA and Bax were significantly induced by cisplatin in p53-wild type A2780s cell line, but in other three p53-mutant (SKOV3, OVCAR-3 and A2780cp) ovarian cancer cell lines, the expressions of p73, p21waf1/cip1, NOXA and Bax remained unchanged (Figure 1B and C), indicating that the responses of NOXA and Bax to cisplatin are regulated mainly by p53 other than p73 in ovarian cancer cell lines. The gene discussed is PMAIP1; the disease is ovarian carcinoma.