PTPN2 and hyperinsulinemic hypoglycemia, familial, 4: Further studies should focus on delineating the precise cellular and molecular mechanisms that underlie the strain-dependent differences in bone development and potentially bone marrow stroma in Ptpn2−/− mice and the relative contributions of bone to the perturbations in hematopoiesis and erythropoiesis and the morbidity and mortality that are associated with global TCPTP-deficiency.