FOXA1 and neoplasm: While it will be important for other research groups to validate our finding that FOXA1 expression is uniformly positive in Ta stage tumors, it is important to point out that the significant association between loss of FOXA1 and increasing tumor grade (p<0.001) and stage (Ta, T1, T2 vs. T3, T4) remains for both UCC (p = 0.009) and SCC (p = 0.002) when the University of Virginia cohort is analyzed alone.