Since other FOX proteins have been implicated in the development and progression of a variety of malignancies [8], we initiated a study to interrogate FOXA family member expression in human bladder cancer cell lines and in human tumor samples, as well as to determine the functional role of FOXA1 in a tissue recombination model of urothelial tumor cell biology. The gene discussed is FOXA1; the disease is urinary bladder carcinoma.