In α2/β1 integrin double-transgenic mice, skin irritation led to a chronic condition resembling psoriasis with persistent hyperplasia, cutaneous influx of CD4+ and CD8+ T-lymphocytes and secretion of pro-inflammatory cytokines like TNF-α, IFN-γ, IL-1β and IL-6 [62]. The gene discussed is CD4; the disease is psoriasis.