ITGB1 and psoriasis: Subrabasal overexpression of α2 and/or β1 integrin (encoded by the human ITGA2 and ITGB1 genes, respectively) has previously been shown to entail dysregulation of epidermal proliferation and differentiation in mice, leading to cutaneous influx of activated cells of the leukocyte lineage and development of a psoriasis-like phenotype [14].