Intronic variation located in a 92-kb interval within the Transcription Factor 7-Like 2 (TCF7L2) gene locus, a transcriptional regulator of canonical Wnt signaling [1], [2], is the strongest determinant for type 2 diabetes (T2D) susceptibility identified to date [3], [4], [5]. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.