NRG1 and Cognitive impairment: Interestingly, BACE1 and Aph1BC (a component of the gamma secretase complex) knock-out mouse models, in which NRG1 cleavage is impaired, exhibit alterations in behaviors such as deficits in prepulse inhibition, cognitive impairments, alterations in social recognition and interaction [9]–[10], suggesting that imbalances in NRG1 cleavage may cause behavioral abnormalities similar to those observed in SCZ.