Peripheral or central hyperglycemia inhibits AMPK in several hypothalamic nuclei, the arcuate nucleus (ARC), the ventromedial hypothalamus (VMH)/dorsomedial hypothalamus (DMH), the paraventricular nucleus (PVN) and the lateral hypothalamus (LH) [16], [17] whereas insulin-induced hypoglycaemia or 2-deoxy-D-glucose (2DG)-induced glucopenia activates AMPK [16], [18], [19]. Here, INS is linked to Hypoglycemia.