Since our previous studies showed that the expression level of FKBP5 was correlated with the sensitivity of pancreatic cancer cells to chemotherapeutic drugs [10], we next determined whether knockdown of FKBP5 could affect the chemosensitivity of SU86 xenografts to gemcitabine in vivo. The gene discussed is FKBP5; the disease is familial pancreatic carcinoma.